Antibody Name:	ACOT11 Antibody (PACO15261)
Antibody SKU:	PACO15261
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse
Immunogen:	Fusion protein of human ACOT11

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15261(ACOT11 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
	Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal kidney tissue, Human fetal lung tissue, Primary antibody: PACO15261(ACOT11 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds.
	The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15261(ACOT11 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).

Background:

This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acid, to the corresponding non-esterified fatty acid, and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants.

Synonyms:

Acyl-CoA thioesterase 11

UniProt Protein Function:	ACOT11: Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Hydrolase; EC 3.1.2.-Chromosomal Location of Human Ortholog: 1p32.3Cellular Component: cytoplasmMolecular Function: acyl-CoA hydrolase activity; lipid bindingBiological Process: response to temperature stimulus; response to cold; fatty acid metabolic process
UniProt Protein Details:
NCBI Summary:	This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
UniProt Code:	Q8WXI4
NCBI GenInfo Identifier:	21363000
NCBI Gene ID:	26027
NCBI Accession:	Q8WXI4.1
UniProt Secondary Accession:	Q8WXI4,O75187, Q52LP1, Q53ER9, Q96DI1, Q9H883, B1AQ22 D3DQ50
UniProt Related Accession:	Q8WXI4
Molecular Weight:	67,152 Da
NCBI Full Name:	Acyl-coenzyme A thioesterase 11
NCBI Synonym Full Names:	acyl-CoA thioesterase 11
NCBI Official Symbol:	ACOT11
NCBI Official Synonym Symbols:	BFIT; THEA; THEM1; STARD14
NCBI Protein Information:	acyl-coenzyme A thioesterase 11; START domain containing 14; acyl-CoA thioester hydrolase 11; adipose-associated thioesterase; brown fat-inducible thioesterase; thioesterase, adipose associated; thioesterase superfamily member 1; StAR-related lipid transfer (START) domain containing 14
UniProt Protein Name:	Acyl-coenzyme A thioesterase 11
UniProt Synonym Protein Names:	Acyl-CoA thioester hydrolase 11; Adipose-associated thioesterase; Brown fat-inducible thioesterase; BFIT
Protein Family:	Acyl-coenzyme A thioesterase
UniProt Gene Name:	ACOT11
UniProt Entry Name:	ACO11_HUMAN