ACOD1 Antibody (PACO45950)
- SKU:
- PACO45950
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ACOD1 Antibody (PACO45950) |
| Antibody SKU: | PACO45950 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Cis-aconitate decarboxylase protein (57-257AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human glioma using PACO45950 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human appendix tissue using PACO45950 at dilution of 1:100. |
| Background: | Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid, production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation. |
| Synonyms: | Cis-aconitate decarboxylase (CAD) (EC 4.1.1.6) (Aconitate decarboxylase) (Aconitate decarboxylase 1) (Cis-aconitic acid, decarboxylase) (Immune-responsive gene 1 protein), ACOD1, IRG1 |
| UniProt Protein Function: | IRG1: Belongs to the PrpD family.Protein type: EC 4.1.1.6Chromosomal Location of Human Ortholog: 13q22.3Cellular Component: mitochondrionMolecular Function: aconitate decarboxylase activityBiological Process: defense response; embryo implantation; inhibition of NF-kappaB transcription factor; metabolic process; negative regulation of inflammatory response; negative regulation of innate immune response; negative regulation of interferon type I production; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; positive regulation of antimicrobial humoral response |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | A6NK06 |
| NCBI GenInfo Identifier: | 193806684 |
| NCBI Gene ID: | 730249 |
| NCBI Accession: | A6NK06.1 |
| UniProt Secondary Accession: | A6NK06 |
| UniProt Related Accession: | A6NK06 |
| Molecular Weight: | 52,628 Da |
| NCBI Full Name: | Cis-aconitate decarboxylase |
| NCBI Synonym Full Names: | aconitate decarboxylase 1 |
| NCBI Official Symbol: | ACOD1 |
| NCBI Official Synonym Symbols: | CAD; IRG1 |
| NCBI Protein Information: | cis-aconitate decarboxylase |
| UniProt Protein Name: | Cis-aconitate decarboxylase |
| UniProt Synonym Protein Names: | Aconitate decarboxylase; Aconitate decarboxylase 1 |
| Protein Family: | |
| UniProt Gene Name: | ACOD1 |
| UniProt Entry Name: | IRG1_HUMAN |
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