Name: Acetyl-NFE4 (K43) Antibody (PACO06074)
SKU: PACO06074
Availability: OutOfStock

Antibody Name:	Acetyl-NFE4 (K43) Antibody (PACO06074)
Antibody SKU:	PACO06074
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:20000, WB:1:500-1:2000
Species Reactivity:	Human
Immunogen:	Synthesized peptide derived from the human NF-E4 around the acetylation site of K43.

Form:	Liquid
Storage Buffer:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western Blot analysis of AD-293 cells using Acetyl-NF-E4 (K43) Polyclonal Antibody.
	Western Blot analysis of AD-293 cells using Acetyl-NF-E4 (K43) Polyclonal Antibody.

Synonyms:

NFE4; Transcription factor NF-E4

UniProt Protein Function:	NF-E4: Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma- globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter. 2 isoforms of the human protein are produced by alternative initiation.Chromosomal Location of Human Ortholog: 7q22.1
UniProt Protein Details:
NCBI Summary:	The erythroid-specific protein encoded by this gene, and the ubiquitous transcription factor CP2, form the stage selector protein (SSP) complex, which is involved in preferential expression of the gamma-globin genes in fetal erythroid cells. Alternate use of an in-frame upstream non-AUG (CUG) translation initiation codon, and a downstream AUG codon, results in two isoforms. While the long isoform (22 kDa) acts as an activator, the short isoform (14 kDa) has been shown to repress gamma-globin gene expression. This gene is located in an intron of the FBXL13 gene on the opposite strand. [provided by RefSeq, Jul 2008]
UniProt Code:	Q86UQ8
NCBI GenInfo Identifier:	74714021
NCBI Gene ID:	58160
NCBI Accession:	Q86UQ8.1
UniProt Secondary Accession:	Q86UQ8
UniProt Related Accession:	Q86UQ8
Molecular Weight:	8,356 Da
NCBI Full Name:	Transcription factor NF-E4
NCBI Synonym Full Names:	nuclear factor, erythroid 4
NCBI Official Symbol:	NFE4
NCBI Official Synonym Symbols:	NF-E4
NCBI Protein Information:	transcription factor NF-E4
UniProt Protein Name:	Transcription factor NF-E4
UniProt Synonym Protein Names:
Protein Family:	Transcription factor
UniProt Gene Name:	NFE4
UniProt Entry Name:	NFE4_HUMAN