Description
Antibody Name: | Acetyl-NFE4 (K43) Antibody (PACO06074) |
Antibody SKU: | PACO06074 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from the human NF-E4 around the acetylation site of K43. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot analysis of AD-293 cells using Acetyl-NF-E4 (K43) Polyclonal Antibody. | |
Western Blot analysis of AD-293 cells using Acetyl-NF-E4 (K43) Polyclonal Antibody. |
Synonyms: | NFE4; Transcription factor NF-E4 |
UniProt Protein Function: | NF-E4: Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma- globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter. 2 isoforms of the human protein are produced by alternative initiation.Chromosomal Location of Human Ortholog: 7q22.1 |
UniProt Protein Details: | |
NCBI Summary: | The erythroid-specific protein encoded by this gene, and the ubiquitous transcription factor CP2, form the stage selector protein (SSP) complex, which is involved in preferential expression of the gamma-globin genes in fetal erythroid cells. Alternate use of an in-frame upstream non-AUG (CUG) translation initiation codon, and a downstream AUG codon, results in two isoforms. While the long isoform (22 kDa) acts as an activator, the short isoform (14 kDa) has been shown to repress gamma-globin gene expression. This gene is located in an intron of the FBXL13 gene on the opposite strand. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q86UQ8 |
NCBI GenInfo Identifier: | 74714021 |
NCBI Gene ID: | 58160 |
NCBI Accession: | Q86UQ8.1 |
UniProt Secondary Accession: | Q86UQ8 |
UniProt Related Accession: | Q86UQ8 |
Molecular Weight: | 8,356 Da |
NCBI Full Name: | Transcription factor NF-E4 |
NCBI Synonym Full Names: | nuclear factor, erythroid 4 |
NCBI Official Symbol: | NFE4 |
NCBI Official Synonym Symbols: | NF-E4 |
NCBI Protein Information: | transcription factor NF-E4 |
UniProt Protein Name: | Transcription factor NF-E4 |
UniProt Synonym Protein Names: | |
Protein Family: | Transcription factor |
UniProt Gene Name: | NFE4 |
UniProt Entry Name: | NFE4_HUMAN |