| UniProt Protein Function: | H2B1A: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Transcribed exclusively in testis, and the corresponding protein is also present in mature sperm. Belongs to the histone H2B family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 6p22.2Cellular Component: extrinsic to plasma membrane; nuclear chromosome, telomeric region; nucleoplasm; nucleosome; nucleusMolecular Function: DNA binding; protein heterodimerization activityBiological Process: establishment and/or maintenance of chromatin architecture; inflammatory response; nucleosome assembly; nucleosome disassembly; plasminogen activation; positive regulation of binding; spermatogenesis, exchange of chromosomal proteins |
| UniProt Protein Details: | |
| NCBI Summary: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015] |
| UniProt Code: | Q96A08 |
| NCBI GenInfo Identifier: | 51316070 |
| NCBI Gene ID: | 255626 |
| NCBI Accession: | Q96A08.3 |
| UniProt Secondary Accession: | Q96A08,Q6NZ98, Q6NZA0, Q6NZA1, B2R544 |
| UniProt Related Accession: | Q96A08 |
| Molecular Weight: | 14,167 Da |
| NCBI Full Name: | Histone H2B type 1-A |
| NCBI Synonym Full Names: | histone cluster 1, H2ba |
| NCBI Official Symbol: | HIST1H2BA |
| NCBI Official Synonym Symbols: | STBP; TH2B; H2BFU; TSH2B; TSH2B.1; bA317E16.3 |
| NCBI Protein Information: | histone H2B type 1-A |
| UniProt Protein Name: | Histone H2B type 1-A |
| UniProt Synonym Protein Names: | Histone H2B, testis; TSH2B.1; Testis-specific histone H2B |
| Protein Family: | Histone |
| UniProt Gene Name: | HIST1H2BA |
| UniProt Entry Name: | H2B1A_HUMAN |
