Description
Antibody Name: | ACER2 Antibody (PACO07237) |
Antibody SKU: | PACO07237 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:10000, WB:1:500-1:2000, IHC-p:1:100-1:300 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from the Internal region of human ASAH3L. at AA rangle: 50-130 |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemical analysis of paraffin-embedded human-breast-cancer, antibody was diluted at 1:200. | |
Immunohistochemical analysis of paraffin-embedded human-breast-cancer, antibody was diluted at 1:200. | |
Western blot analysis of COS7 using ASAH3L antibody. Secondary antibody was diluted at 1:20000. |
Synonyms: | ACER2; ASAH3L; PP11646; Alkaline ceramidase 2; AlkCDase 2; Alkaline CDase 2; haCER2; Acylsphingosine deacylase 3-like; N-acylsphingosine amidohydrolase 3-like |
UniProt Protein Function: | ACER2: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)- ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)- ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate. Belongs to the alkaline ceramidase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integral; Lipid Metabolism - sphingolipid; EC 3.5.1.23; HydrolaseChromosomal Location of Human Ortholog: 9p22.1Cellular Component: Golgi membrane; Golgi apparatus; integral to Golgi membraneMolecular Function: ceramidase activityBiological Process: caspase activation; response to retinoic acid; sphingolipid metabolic process; sphingolipid biosynthetic process; positive regulation of cell proliferation; sphingosine biosynthetic process; negative regulation of cell-matrix adhesion; ceramide metabolic process; negative regulation of cell adhesion mediated by integrin |
UniProt Protein Details: | |
NCBI Summary: | The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010] |
UniProt Code: | Q5QJU3 |
NCBI GenInfo Identifier: | 71043498 |
NCBI Gene ID: | 340485 |
NCBI Accession: | NP_001010887.2 |
UniProt Secondary Accession: | Q5QJU3,Q569G5, Q5VZR7, Q71RD2, A2A3R8 |
UniProt Related Accession: | Q5QJU3 |
Molecular Weight: | 15,864 Da |
NCBI Full Name: | alkaline ceramidase 2 |
NCBI Synonym Full Names: | alkaline ceramidase 2 |
NCBI Official Symbol: | ACER2 |
NCBI Official Synonym Symbols: | ASAH3L; ALKCDase2 |
NCBI Protein Information: | alkaline ceramidase 2; haCER2; alkCDase 2; alkaline CDase 2; ceramide hydrolase |
UniProt Protein Name: | Alkaline ceramidase 2 |
UniProt Synonym Protein Names: | Acylsphingosine deacylase 3-like; N-acylsphingosine amidohydrolase 3-like |
Protein Family: | Alkaline ceramidase |
UniProt Gene Name: | ACER2 |
UniProt Entry Name: | ACER2_HUMAN |