Description
Antibody Name: | ACER1 Antibody (PACO07204) |
Antibody SKU: | PACO07204 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:10000, WB:1:500-1:2000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from the Internal region of human ASAH3. at AA rangle: 100-180 |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of HepG2 using ASAH3 antibody. Secondary antibody was diluted at 1:20000. |
Synonyms: | ACER1; ASAH3; Alkaline ceramidase 1; AlkCDase 1; Alkaline CDase 1; Acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3 |
UniProt Protein Function: | ACER1: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids. Belongs to the alkaline ceramidase family.Protein type: Hydrolase; Membrane protein, multi-pass; EC 3.5.1.23; Membrane protein, integral; Lipid Metabolism - sphingolipid; Endoplasmic reticulumChromosomal Location of Human Ortholog: 19p13.3Cellular Component: endoplasmic reticulum; endoplasmic reticulum membraneMolecular Function: ceramidase activityBiological Process: cell differentiation; ceramide catabolic process; epidermis development; keratinocyte differentiation; response to alkalinity; sphingolipid biosynthetic process; sphingolipid metabolic process; sphingosine biosynthetic process |
UniProt Protein Details: | |
NCBI Summary: | Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010] |
UniProt Code: | Q8TDN7 |
NCBI GenInfo Identifier: | 74715919 |
NCBI Gene ID: | 125981 |
NCBI Accession: | Q8TDN7.1 |
UniProt Secondary Accession: | Q8TDN7 |
UniProt Related Accession: | Q8TDN7 |
Molecular Weight: | 31,095 Da |
NCBI Full Name: | Alkaline ceramidase 1 |
NCBI Synonym Full Names: | alkaline ceramidase 1 |
NCBI Official Symbol: | ACER1 |
NCBI Official Synonym Symbols: | ASAH3; ALKCDase1 |
NCBI Protein Information: | alkaline ceramidase 1 |
UniProt Protein Name: | Alkaline ceramidase 1 |
UniProt Synonym Protein Names: | Acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3 |
Protein Family: | Alkaline ceramidase |
UniProt Gene Name: | ACER1 |
UniProt Entry Name: | ACER1_HUMAN |