ACC1 Polyclonal Antibody
- SKU:
- CAB21752
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | ACC1 Polyclonal Antibody |
| Product Code: | CAB21752 |
| Reactivity: | Human, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:500-1:2000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | 293T |
| Cellular Location: | Cytoplasm |
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1190-1340 of human ACC1 (NP_942133.1). |
| Sequence: | NRGNI PTLNR MSFSS NLNHY GMTHV ASVSD VLLDN SFTPP CQRMG GMVSF RTFED FVRIF DEVMG CFSDS PPQSP TFPEA GHTSL YDEDK VPRDE PIHIL NVAIK TDCDI EDDRL AAMFR EFTQQ NKATL VDHGI RRLTF LVAQK DFRKQ V |
| Synonyms: | ACC, ACAC, ACC1, ACCA, Acac1, hACC1, ACACAD, ACCalpha, ACACalpha |
| Calculated MW: | 266kDa |
| Observed MW: | 265kDa |
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