Antibody Name:	ABLIM1 Antibody (PACO15241)
Antibody SKU:	PACO15241
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:15-1:50
Species Reactivity:	Human, Mouse
Immunogen:	Fusion protein of human ABLIM1

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: PACO15241(ABLIM1 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
	The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO15241(ABLIM1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).

Background:

This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified.

Synonyms:

Actin binding LIM protein 1

UniProt Protein Function:	abLIM: a cytoskeletal LIM protein consisting of a C-terminal cytoskeletal domain fused to an N-terminal domain of four double zinc finger motifs. The C-terminal domain is 50% identical to dematin, an actin-bundling protein of the erythroid cytoskeleton. Undergoes extensive phosphorylation in light-adapted retinas in vivo and its developmental expression in the retina coincides with the elaboration of photoreceptor inner and outer segments. Three distinct splice variant isoforms have been described: ABLIM-l, ABLIM-m, ABLIM-s.Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Actin-bindingChromosomal Location of Human Ortholog: 10q25Cellular Component: lamellipodium; cytoplasm; stress fiber; actin cytoskeletonMolecular Function: protein binding; zinc ion binding; actin bindingBiological Process: lamellipodium biogenesis; axon guidance; organ morphogenesis; visual perception; cilium biogenesis; positive regulation of transcription from RNA polymerase II promoter; cytoskeleton organization and biogenesis
UniProt Protein Details:
NCBI Summary:	This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:	O14639
NCBI GenInfo Identifier:	206729924
NCBI Gene ID:	3983
NCBI Accession:	O14639.3
UniProt Secondary Accession:	O14639,Q15039, Q5JVV1, Q5JVV2, Q5T6N3, Q5T6N5, Q68CQ9 Q9BUP1, A6NI16, A6NJ06
UniProt Related Accession:	O14639
Molecular Weight:	52,056 Da
NCBI Full Name:	Actin-binding LIM protein 1
NCBI Synonym Full Names:	actin binding LIM protein 1
NCBI Official Symbol:	ABLIM1
NCBI Official Synonym Symbols:	ABLIM; LIMAB1; LIMATIN; abLIM-1
NCBI Protein Information:	actin-binding LIM protein 1; actin-binding double-zinc-finger protein; actin-binding LIM protein family member 1
UniProt Protein Name:	Actin-binding LIM protein 1
UniProt Synonym Protein Names:	Actin-binding LIM protein family member 1; Actin-binding double zinc finger protein; LIMAB1; Limatin
Protein Family:	Actin-binding LIM protein
UniProt Gene Name:	ABLIM1
UniProt Entry Name:	ABLM1_HUMAN