Description
| Product Name: | ABCA1 Monoclonal Antibody |
| Product Code: | CAB21976 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC54239 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | IF/ICC, ELISA |
| Key Applications: | Immunofluorescence |
| Recommended Dilution: | IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Membrane, Multi-pass membrane protein |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1170-1350 of human ABCA1 (NP_005493.2). |
| Sequence: | DHESD TLTID VSAIS NLIRK HVSEA RLVED IGHEL TYVLP YEAAK EGAFV ELFHE IDDRL SDLGI SSYGI SETTL EEIFL KVAEE SGVDA ETSDG TLPAR RNRRA FGDKQ SCLRP FTEDD AADPN DSDID PESRE TDLLS GMDGK GSYQV KGWKL TQQQF VALLW KRLLI ARRSR KGFFA Q |
| Synonyms: | TGD, ABC1, CERP, ABC-1, HDLDT1, HPALP1, HDLCQTL13 |
| Calculated MW: | 254kDa |
| Observed MW: | Refer to figures |
