Antibody Name:	AATK Antibody (PACO17472)
Antibody SKU:	PACO17472
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:25-1:100
Species Reactivity:	Human
Immunogen:	Synthetic peptide of human AATK

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO17472(AATK Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO17472(AATK Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms:

Apoptosis-associated tyrosine kinase

UniProt Protein Function:	Lmr1: a protein kinase kinase of the Lmr family. Predominantly expressed in the nervous system and is involved in neurite extension and apoptosis of cerebellar granule cells. Contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. May be necessary for the induction of growth arrest and/or apoptosis of myeloid cells induced by cytokine withdrawal, such as IL3, and during G-CSF-induced terminal differentiation of myeloblasts to granulocytes. Four alternatively spliced isoforms have been reported.Protein type: Membrane protein, integral; EC 2.7.11.1; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; Lmr familyChromosomal Location of Human Ortholog: 17q25.3
UniProt Protein Details:
NCBI Summary:	The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
UniProt Code:	Q6ZMQ8
NCBI GenInfo Identifier:	114149222
NCBI Gene ID:	9625
NCBI Accession:	Q6ZMQ8.2
UniProt Secondary Accession:	Q6ZMQ8,O75136, Q6ZN31, Q86X28
UniProt Related Accession:	Q6ZMQ8
Molecular Weight:	93,226 Da
NCBI Full Name:	Serine/threonine-protein kinase LMTK1
NCBI Synonym Full Names:	apoptosis associated tyrosine kinase
NCBI Official Symbol:	AATK
NCBI Official Synonym Symbols:	LMR1; AATYK; LMTK1; p35BP; AATYK1; PPP1R77
NCBI Protein Information:	serine/threonine-protein kinase LMTK1
UniProt Protein Name:	Serine/threonine-protein kinase LMTK1
UniProt Synonym Protein Names:	Apoptosis-associated tyrosine kinase; AATYK; Brain apoptosis-associated tyrosine kinase; CDK5-binding protein; Lemur tyrosine kinase 1; p35-binding protein; p35BP
Protein Family:	Serine/threonine-protein kinase
UniProt Gene Name:	AATK
UniProt Entry Name:	LMTK1_HUMAN