AAK1 Antibody (PACO00349)

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SKU:
PACO00349

Description

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Antibody Name:AAK1 Antibody
Antibody SKU:PACO00349
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat, Monkey
Immunogen:synthesized peptide derived from the Internal region of human AAK1.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:AAK1; KIAA1048; AP2-associated protein kinase 1; Adaptor-associated kinase 1
UniProt Protein Function:AAK1: an NAK kinase. Plays a regulatory role in clathrin-mediated endocytosis, including the regulation of fatty acid synthesis and cholesterol synthesis.
UniProt Protein Details:

Protein type:Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, Other; Other group; NAK family

Chromosomal Location of Human Ortholog: 2p14

Cellular Component: clathrin-coated vesicle; cytoplasm; extrinsic to plasma membrane; leading edge; terminal button

Molecular Function:Notch binding; protein binding; protein serine/threonine kinase activity

Biological Process: positive regulation of Notch signaling pathway; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein stabilization; regulation of protein localization

NCBI Summary:Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:Q2M2I8
NCBI GenInfo Identifier:300669613
NCBI Gene ID:22848
NCBI Accession:Q2M2I8.3
UniProt Secondary Accession:Q2M2I8,Q4ZFZ3, Q53RX6, Q9UPV4,
UniProt Related Accession:Q2M2I8
Molecular Weight:93,578 Da
NCBI Full Name:AP2-associated protein kinase 1
NCBI Synonym Full Names:AP2 associated kinase 1
NCBI Official Symbol:AAK1  
NCBI Protein Information:AP2-associated protein kinase 1
UniProt Protein Name:AP2-associated protein kinase 1
UniProt Synonym Protein Names:Adaptor-associated kinase 1
Protein Family:AP2-associated protein kinase
UniProt Gene Name:AAK1  
UniProt Entry Name:AAK1_HUMAN
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Additional Information

Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Reactivity:
NHP - Monkey
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Applications:
WB
Applications:
IHC
Applications:
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
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