4-1BB/CD137 Monoclonal Antibody

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SKU:
CAB22167
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB

Description

Product Name:4-1BB/CD137 Monoclonal Antibody
Product Code:CAB22167
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC55368
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:2000-1:20000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:293T-4-1BB/CD137
Cellular Location:Membrane, Single-pass type I membrane protein

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 24-186 of human 4-1BB/CD137 (NP_001552.2).
Sequence:LQDPC SNCPA GTFCD NNRNQ ICSPC PPNSF SSAGG QRTCD ICRQC KGVFR TRKEC SSTSN AECDC TPGFH CLGAG CSMCE QDCKQ GQELT KKGCK DCCFG TFNDQ KRGIC RPWTN CSLDG KSVLV NGTKE RDVVC GPSPA DLSPG ASSVT PPAPA REPGH SPQ
Synonyms:ILA, 4-1BB, CD137, CDw137, IMD109
Calculated MW:28kDa
Observed MW:24-28kDa 40-50kDa
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